SUBSTITUTED INDOLES AND METHODS OF USE THEREOF

SUBSTITUTED INDOLES AND METHODS OF USE THEREOF

The present disclosure provides substituted indole compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification. The present disclosure is also directed to the use of compounds...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FOLEY, Megan Alene Cloonan, LAMPE, John, REITER, Lawrence Alan, DUNCAN, Kenneth, MUNCHHOF, Michael John, HARVEY, Darren Martin, THOMENIUS, Michael, CAMPBELL, John
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present disclosure provides substituted indole compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject. La présente invention concerne des composés d'indole substitués de formule I : (I) et des sels et solvates pharmaceutiquement acceptables de ceux-ci, dans la formule, R1a, R1e, G1, G2, Q1, Q2, Q3 et (II) sont tels que définis dans la spécification. La présente invention concerne également l'utilisation des composés de formule I pour traiter une maladie, un trouble, ou une affection comme le cancer chez un sujet.