OLIGONUCLEOTIDE COMPOSITIONS FOR TARGETING CCR2 AND CSF1R AND USES THEREOF

The present invention is based, in part, on providing oligonucleotide compositions for targeting CCR2, CSF1R, and/or both CCR2 and CSF1R, as well as methods of use thereof, such as to modulate myeloid-derive cell inflammatory phenotypes and immune responses that are mediated by such cells. La présen...

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Bibliographische Detailangaben
Hauptverfasser:	KAUFFMAN, Kevin, NOVOBRANTSEVA, Tatiana
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is based, in part, on providing oligonucleotide compositions for targeting CCR2, CSF1R, and/or both CCR2 and CSF1R, as well as methods of use thereof, such as to modulate myeloid-derive cell inflammatory phenotypes and immune responses that are mediated by such cells. La présente invention est basée, en partie, sur la fourniture de compositions oligonucléotidiques pour cibler CCR2, CSF1R, et/ou à la fois CCR2 et CSF1R, ainsi que des procédés d'utilisation de ceux-ci, de manière à moduler des phénotypes inflammatoires de cellules dérivées de myéloïde et des réponses immunitaires qui sont médiées par de telles cellules.