NOVEL SESQUITERPENOID ANALOGS

The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitiz...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	DAVIS, Dexter Cameron, ADIBEKIAN, Alexander, DAI, Mingji, HOCH, Dominic Gregor, ZHANG, Zhong-Yin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers. La présente invention concerne de nouveaux composés sesquiterpénoïdes servant d'inhibiteurs de SHP2 et/ou de POLE3 pour le traitement potentiel de cancers, et des procédés de fabrication et d'utilisation des composés sesquiterpénoïdes. La présente invention concerne un procédé d'utilisation de ces composés utilisés en tant qu'agent de chimiosensibilisation de médicaments endommageant l'ADN pour des cancers.