IMMUNE MODIFYING PARTICLES FOR THE TREATMENT OF CANCER

The present disclosure provides methods of treating cancer and proliferative diseases using immune-modifying particles in combination with cancer therapeutics, such as checkpoint inhibitors or biologic agents, to modify the activity of myeloid-derived suppressor cells (MDSCs), tumor-associated macro...

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Bibliographische Detailangaben
1. Verfasser:	PUISIS, John
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides methods of treating cancer and proliferative diseases using immune-modifying particles in combination with cancer therapeutics, such as checkpoint inhibitors or biologic agents, to modify the activity of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), neutrophils, monocytes, and/or tumor-associated stroma associated with promoting tumor growth and metastasis. La présente invention concerne des méthodes pour traiter le cancer et les maladies prolifératives en utilisant des particules modifiant la réponse immunitaire en association avec des agents thérapeutiques anticancéreux, tels que des inhibiteurs de points de contrôle ou des agents biologiques, afin de modifier l'activité des cellules myéloïdes suppressives (MDSC), des macrophages associés à la tumeur (TAM), des neutrophiles, des monocytes et/ou du stroma associé à la tumeur, associés à la stimulation de la croissance tumorale et de la métastase.