THERAPEUTIC AGENT FOR CARTILAGE DISEASE

The present disclosure addresses the problem of providing a novel therapeutic agent, for cartilage disease, that has cartilage-regenerating action. Because substances having SIK2 inhibitory action have chondrocyte-differentiation-inducing action, a therapeutic agent formed so as to contain a substan...

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Bibliographische Detailangaben
Hauptverfasser:	TSUMORI, Yuki, NAKANISHI, Yasutomo, FUJIMURA, Shinsei
Format:	Patent
Sprache:	eng ; fre ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure addresses the problem of providing a novel therapeutic agent, for cartilage disease, that has cartilage-regenerating action. Because substances having SIK2 inhibitory action have chondrocyte-differentiation-inducing action, a therapeutic agent formed so as to contain a substance having SIK2-inhibitory action is useful as a therapeutic agent, having cartilage-regenerating action, for cartilage damage or cartilage diseases such as osteoarthritis. Le but de la présente invention est de fournir un nouvel agent thérapeutique, pour une maladie du cartilage, qui a une action de régénération du cartilage. En raison du fait que les substances ayant une action inhibitrice de SIK2 ont une action induisant la différenciation des chondrocytes, un agent thérapeutique formé de manière à contenir une substance ayant une action inhibitrice de SIK2 est utile en tant qu'agent thérapeutique, ayant une action de régénération du cartilage, pour des lésions du cartilage ou des maladies du cartilage telles que l'arthrose. 本開示の課題は、軟骨再生作用を有する新規な軟骨関連疾患治療剤を提供することである。ＳＩＫ２阻害作用を有する物質は軟骨細胞分化亢進作用を有するため、ＳＩＫ２阻害作用を有する物質を含んでなる治療剤は、軟骨損傷、または変形性関節症といった軟骨関連疾患に対し、軟骨再生作用を有する治療剤として有用である。