PROTEIN RECOGNIZING DRUG MOIETY OF ANTIBODY-DRUG CONJUGATE

A protein that recognizes the drug moiety of an antibody-drug conjugate in which a drug represented by the formula is linked to an antibody via a linker; a method for measuring the concentration of the antibody-drug conjugate in the plasma of a mammal dosed with the antibody-drug conjugate using the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	KAWAMURA Junko, MASUDA Takeshi, YASUDA Satoru, SOMA Masako, KUGA Hiroshi, ISHIBASHI Hiromi
Format:	Patent
Sprache:	eng ; fre ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A protein that recognizes the drug moiety of an antibody-drug conjugate in which a drug represented by the formula is linked to an antibody via a linker; a method for measuring the concentration of the antibody-drug conjugate in the plasma of a mammal dosed with the antibody-drug conjugate using the protein; and a method for checking the tissue distribution of the antibody-drug conjugate in the mammal using the protein. L'invention concerne une protéine qui reconnaît la fraction médicamenteuse d'un conjugué anticorps-médicament dans lequel un médicament représenté par la formule est lié à un anticorps par l'intermédiaire d'un lieur ; un procédé pour mesurer la concentration du conjugué anticorps-médicament dans le plasma d'un mammifère dosé avec le conjugué anticorps-médicament à l'aide de la protéine ; et un procédé pour vérifier la distribution tissulaire du conjugué anticorps-médicament chez le mammifère à l'aide de la protéine. 下式で示される薬物と、抗体とが、リンカーを介して結合した抗体－薬物コンジュゲートの、薬物部位を認識する蛋白質、及び該蛋白質を用いて、上記の抗体－薬物コンジュゲートを投与された哺乳動物における、該抗体－薬物コンジュゲートの血漿中濃度を定量する方法及び組織分布を確認する方法。