ANTIBODIES BINDING TO VISTA AT ACIDIC PH

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SU, Lin Hui, NAYEEM, Akbar, LEMAR, Hadia, KORMAN, Alan J, SHEPPARD, Paul O, QUIGLEY, Michael, CRITTON, David A, RAJPAL, Arvind, DENG, Xiaodi, BORGES, Luis, RANKIN, Andrew, HUANG, Richard Y, CHEN, Guodong, JOHNSTON, Robert J, DEYANOVA, Ekaterina G, PINCKNEY, Jason R, BAHJAT, Keith Sadoon, RAKESTRAW, Ginger
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH. L'invention concerne des anticorps qui se lient spécifiquement au suppresseur de type immunoglobuline à domaine V de l'activation des lymphocytes T (VISTA) à un pH acide, et leur utilisation dans le traitement du cancer. Dans certains modes de réalisation, les anticorps se lient de manière spécifique au VISTA humain à un pH acide, mais ne se lient pas de façon significative au VISTA humain à un pH neutre ou physiologique.