NOVEL THYROID PEROXIDASE AUTOANTIBODY IMMUNOASSAY

Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid...

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Bibliographische Detailangaben
Hauptverfasser:	CHERIAN, Saji, POLADIAN, Maral, SINHA, Seema, HAN, Aili, D'AGOSTINO, Paul, JAGGI, Kuldeep, SAHAKIAN, Niver, CORTESE, Kayla, HAMMARQUIST, Gabriel, TEWARI, Prakash, LEE, Haekyung
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO. L'invention concerne des dosages immunologiques permettant de détecter un anticorps de peroxydase anti-thyroïdienne dans un échantillon biologique provenant d'un sujet et/ou de diagnostiquer une maladie thyroïdienne chez un sujet. Les dosages immunologiques décrits utilisent une peroxydase thyroïdienne de singe cynomolgus recombinant (rTPO) et évaluent le niveau de formation ou de rupture induite par anticorps de peroxydase anti-thyroïdienne de complexes comprenant un support solide et la rTPO.