COMPOSITION OF ANTI-TUMOR COMPOUND MEDICINE AND USE THEREOF IN COMBATING TUMOR
Disclosed are a multifunctional anti-tumor compound medicine and the use thereof, wherein the composition of the anti-tumor compound medicine includes an agonist of the innate immune pathway (STING) and an inhibitor of a phosphodiesterase, ENPP1. STING and ENPP1 are both located on the endoplasmic r...
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| creator | CHENG, Hao ZHANG, Yueru PEI, Jianwu TAN, Xiangshi WANG, Xiang |
| description | Disclosed are a multifunctional anti-tumor compound medicine and the use thereof, wherein the composition of the anti-tumor compound medicine includes an agonist of the innate immune pathway (STING) and an inhibitor of a phosphodiesterase, ENPP1. STING and ENPP1 are both located on the endoplasmic reticulum membrane, and the activator and agonist of STING are the hydrolysis substrates of ENPP1. The compound anti-tumor medicine has better tumor-combating efficacies than a natural immune agonist alone.
L'invention concerne un médicament composé antitumoral multifonctionnel et son utilisation, ladite composition comprenant un agoniste de la voie immunitaire innée (STING) et un inhibiteur d'une phosphodiestérase (ENPP1). STING et ENPP1 se situent tous deux sur la membrane du réticulum endoplasmique, et l'activateur et l'agoniste de STING sont les substrats hydrolytiques de ENPP1. Le médicament composé antitumoral de l'invention présente une meilleure efficacité de lutte contre les tumeurs qu'un agoniste immunitai |
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L'invention concerne un médicament composé antitumoral multifonctionnel et son utilisation, ladite composition comprenant un agoniste de la voie immunitaire innée (STING) et un inhibiteur d'une phosphodiestérase (ENPP1). STING et ENPP1 se situent tous deux sur la membrane du réticulum endoplasmique, et l'activateur et l'agoniste de STING sont les substrats hydrolytiques de ENPP1. Le médicament composé antitumoral de l'invention présente une meilleure efficacité de lutte contre les tumeurs qu'un agoniste immunitai</description><language>chi ; eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191212&DB=EPODOC&CC=WO&NR=2019233300A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191212&DB=EPODOC&CC=WO&NR=2019233300A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHENG, Hao</creatorcontrib><creatorcontrib>ZHANG, Yueru</creatorcontrib><creatorcontrib>PEI, Jianwu</creatorcontrib><creatorcontrib>TAN, Xiangshi</creatorcontrib><creatorcontrib>WANG, Xiang</creatorcontrib><title>COMPOSITION OF ANTI-TUMOR COMPOUND MEDICINE AND USE THEREOF IN COMBATING TUMOR</title><description>Disclosed are a multifunctional anti-tumor compound medicine and the use thereof, wherein the composition of the anti-tumor compound medicine includes an agonist of the innate immune pathway (STING) and an inhibitor of a phosphodiesterase, ENPP1. STING and ENPP1 are both located on the endoplasmic reticulum membrane, and the activator and agonist of STING are the hydrolysis substrates of ENPP1. The compound anti-tumor medicine has better tumor-combating efficacies than a natural immune agonist alone.
L'invention concerne un médicament composé antitumoral multifonctionnel et son utilisation, ladite composition comprenant un agoniste de la voie immunitaire innée (STING) et un inhibiteur d'une phosphodiestérase (ENPP1). STING et ENPP1 se situent tous deux sur la membrane du réticulum endoplasmique, et l'activateur et l'agoniste de STING sont les substrats hydrolytiques de ENPP1. Le médicament composé antitumoral de l'invention présente une meilleure efficacité de lutte contre les tumeurs qu'un agoniste immunitai</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBz9vcN8A_2DPH091Pwd1Nw9Avx1A0J9fUPUgDLhPq5KPi6ung6e_q5AiVdFEKDXRVCPFyDXIGKPf1AipwcQzz93BXAmngYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBoaWRsbGxgYGjoTFxqgDXVi9e</recordid><startdate>20191212</startdate><enddate>20191212</enddate><creator>CHENG, Hao</creator><creator>ZHANG, Yueru</creator><creator>PEI, Jianwu</creator><creator>TAN, Xiangshi</creator><creator>WANG, Xiang</creator><scope>EVB</scope></search><sort><creationdate>20191212</creationdate><title>COMPOSITION OF ANTI-TUMOR COMPOUND MEDICINE AND USE THEREOF IN COMBATING TUMOR</title><author>CHENG, Hao ; ZHANG, Yueru ; PEI, Jianwu ; TAN, Xiangshi ; WANG, Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2019233300A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHENG, Hao</creatorcontrib><creatorcontrib>ZHANG, Yueru</creatorcontrib><creatorcontrib>PEI, Jianwu</creatorcontrib><creatorcontrib>TAN, Xiangshi</creatorcontrib><creatorcontrib>WANG, Xiang</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHENG, Hao</au><au>ZHANG, Yueru</au><au>PEI, Jianwu</au><au>TAN, Xiangshi</au><au>WANG, Xiang</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITION OF ANTI-TUMOR COMPOUND MEDICINE AND USE THEREOF IN COMBATING TUMOR</title><date>2019-12-12</date><risdate>2019</risdate><abstract>Disclosed are a multifunctional anti-tumor compound medicine and the use thereof, wherein the composition of the anti-tumor compound medicine includes an agonist of the innate immune pathway (STING) and an inhibitor of a phosphodiesterase, ENPP1. STING and ENPP1 are both located on the endoplasmic reticulum membrane, and the activator and agonist of STING are the hydrolysis substrates of ENPP1. The compound anti-tumor medicine has better tumor-combating efficacies than a natural immune agonist alone.
L'invention concerne un médicament composé antitumoral multifonctionnel et son utilisation, ladite composition comprenant un agoniste de la voie immunitaire innée (STING) et un inhibiteur d'une phosphodiestérase (ENPP1). STING et ENPP1 se situent tous deux sur la membrane du réticulum endoplasmique, et l'activateur et l'agoniste de STING sont les substrats hydrolytiques de ENPP1. Le médicament composé antitumoral de l'invention présente une meilleure efficacité de lutte contre les tumeurs qu'un agoniste immunitai</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOSITION OF ANTI-TUMOR COMPOUND MEDICINE AND USE THEREOF IN COMBATING TUMOR |
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