PLADIENOLIDE COMPOUNDS AND THEIR USE

The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome...

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Bibliographische Detailangaben
Hauptverfasser:	REYNOLDS, Dominic, GERARD, Baudouin, KIRA, Kazunobu, TIVITMAHAISOON, Parcharee, GEARHART, Nicholas C, KOTAKE, Yoshihiko, NAGAO, Satoshi, KANADA SONOBE, Regina Mikie, COOK, Andrew, NEVALAINEN, Marta, LUO, Touping, HAO, Ming-Hong, ENDO, Atsushi, MARCAURELLE, Lisa A, O'SHEA, Morgan Welzel, ZHENG, Guo Zhu, MURAI, Norio, PALACINO, James, ARAI, Kenzo, ELLERY, Shelby, WANG, John, MIYANO, Masayuki, PRAJAPATI, Sudeep, KEANEY, Gregg F, LOWE, Jason T, LIU, Xiang
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy. La présente invention concerne de nouveaux composés de pladiénolide, des compositions pharmaceutiques contenant de tels composés, et des procédés d'utilisation des composés en tant qu'agents thérapeutiques. Ces composés peuvent être utiles dans le traitement de cancers, en particulier de cancers dans lesquels des agents ciblant le complexe d'épissage et des mutations de ceux-ci sont connus pour être utiles. L'invention concerne également des méthodes de traitement de cancers par administration d'au moins un composé de l'invention et d'au moins une thérapie supplémentaire.