INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION

INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION

Compounds of formula (I): wherein,R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treatin...

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Bibliographische Detailangaben
Hauptverfasser: IYANAR, Karthikeyan, PETTIGREW, Jeremy, HARWIG, Curtis, KEREGADDE, Mahesh, CROSS, Jennifer, SEENISAMY, Jeyaprakashnarayanan
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of formula (I): wherein,R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain. L'invention concerne des composés de formule (I) : dans laquelle R1, R2, R3, R4a, R4b et R5 sont définis dans la descritpion, ou un stéréoisomère, énantiomère ou tautomère de ceux-ci ou des mélanges de ceux-ci, ou un sel ou un solvate pharmaceutiquement acceptable de ceux-ci, ainsi que d'autres composés. Ces composés sont utiles dans le traitement de l'inflammation et/ou la douleur. L'invention concerne également des compositions comprenant un composé selon l'invention, ainsi que des procédés d'utilisation des composés pour traiter l'inflammation et/ou la douleur.