COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE
This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according...
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| creator | THAINASHMUTHU, Josephrajan SIBRIAN-VAZQUEZ, Martha BOATMAN, Douglas |
| description | This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.
La présente invention concerne des composés ainsi qu'un procédé de modulation de l'activité de canaux ioniques calciques, y compris des canaux de libération de calcium Ca2+-induit (ou Ca2+ activé) et des canaux de libération de calcium couplés de manière conformationnelle tels que des récepteurs de ryanodine. Certains des composés ont une structure de formule I, ou un stéréoisomère, un tautomère, un hydrate, un solvate, un promédicament ou un sel pharmaceutiquement acceptable de ceux-ci. |
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La présente invention concerne des composés ainsi qu'un procédé de modulation de l'activité de canaux ioniques calciques, y compris des canaux de libération de calcium Ca2+-induit (ou Ca2+ activé) et des canaux de libération de calcium couplés de manière conformationnelle tels que des récepteurs de ryanodine. Certains des composés ont une structure de formule I, ou un stéréoisomère, un tautomère, un hydrate, un solvate, un promédicament ou un sel pharmaceutiquement acceptable de ceux-ci.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191121&DB=EPODOC&CC=WO&NR=2019191502A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191121&DB=EPODOC&CC=WO&NR=2019191502A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>THAINASHMUTHU, Josephrajan</creatorcontrib><creatorcontrib>SIBRIAN-VAZQUEZ, Martha</creatorcontrib><creatorcontrib>BOATMAN, Douglas</creatorcontrib><title>COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE</title><description>This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.
La présente invention concerne des composés ainsi qu'un procédé de modulation de l'activité de canaux ioniques calciques, y compris des canaux de libération de calcium Ca2+-induit (ou Ca2+ activé) et des canaux de libération de calcium couplés de manière conformationnelle tels que des récepteurs de ryanodine. Certains des composés ont une structure de formule I, ou un stéréoisomère, un tautomère, un hydrate, un solvate, un promédicament ou un sel pharmaceutiquement acceptable de ceux-ci.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBw9vcN8A_1cwlWcPMPUggJcnUM8XX1C1Hwd1Nwdgxy8XR0VnAMCvKIDPHw9XQMVnD0c1HwcHUMClFwc_T0CQ1y5WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaGlkBoamDkaGJMnCoAUqQrgw</recordid><startdate>20191121</startdate><enddate>20191121</enddate><creator>THAINASHMUTHU, Josephrajan</creator><creator>SIBRIAN-VAZQUEZ, Martha</creator><creator>BOATMAN, Douglas</creator><scope>EVB</scope></search><sort><creationdate>20191121</creationdate><title>COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE</title><author>THAINASHMUTHU, Josephrajan ; SIBRIAN-VAZQUEZ, Martha ; BOATMAN, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2019191502A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>THAINASHMUTHU, Josephrajan</creatorcontrib><creatorcontrib>SIBRIAN-VAZQUEZ, Martha</creatorcontrib><creatorcontrib>BOATMAN, Douglas</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THAINASHMUTHU, Josephrajan</au><au>SIBRIAN-VAZQUEZ, Martha</au><au>BOATMAN, Douglas</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE</title><date>2019-11-21</date><risdate>2019</risdate><abstract>This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.
La présente invention concerne des composés ainsi qu'un procédé de modulation de l'activité de canaux ioniques calciques, y compris des canaux de libération de calcium Ca2+-induit (ou Ca2+ activé) et des canaux de libération de calcium couplés de manière conformationnelle tels que des récepteurs de ryanodine. Certains des composés ont une structure de formule I, ou un stéréoisomère, un tautomère, un hydrate, un solvate, un promédicament ou un sel pharmaceutiquement acceptable de ceux-ci.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE |
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