COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE

This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according...

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Hauptverfasser:	THAINASHMUTHU, Josephrajan, SIBRIAN-VAZQUEZ, Martha, BOATMAN, Douglas
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof. La présente invention concerne des composés ainsi qu'un procédé de modulation de l'activité de canaux ioniques calciques, y compris des canaux de libération de calcium Ca2+-induit (ou Ca2+ activé) et des canaux de libération de calcium couplés de manière conformationnelle tels que des récepteurs de ryanodine. Certains des composés ont une structure de formule I, ou un stéréoisomère, un tautomère, un hydrate, un solvate, un promédicament ou un sel pharmaceutiquement acceptable de ceux-ci.