ATTENUATED STRAINS OF ONCOLYTIC RHABDOVIRUS AND USES THEREOF IN TUMOR TREATMENT

Provided is a modified matrix protein of a vesicular stomatitis virus, wherein the protein is positioned at the 21st, 51st, 111th and 221st positions, and has at the same time an amino acid replacement. Further provided are the modified matrix protein having the attenuated strains of the vesicular s...

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Bibliographische Detailangaben
Hauptverfasser:	WU, Fei, XIA, Jing, QIN, Frank XiaoFeng
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is a modified matrix protein of a vesicular stomatitis virus, wherein the protein is positioned at the 21st, 51st, 111th and 221st positions, and has at the same time an amino acid replacement. Further provided are the modified matrix protein having the attenuated strains of the vesicular stomatitis virus, a composition containing the attenuated strains, and uses thereof in preparing drugs for controlling abnormal cell proliferation, for inducing and promoting anti-tumor immune response or for eliminating immune inhibition in a tumor tissue microenvironment. Fait l'objet de la présente invention une protéine de matrice modifiée d'un virus de la stomatite vésiculaire, la protéine étant placée en positions 21, 51, 11, et 221 et présentant en même temps une substitution d'un acide aminé. Font aussi l'objet de la présente invention la protéine de la matrice modifiée ayant des couches atténuées du virus de la stomatite vésiculaire et une composition contenant lesdites couches atténuées et leurs applicatio