EYE DROPS IN FORM OF SOLUTION COMPRISING BENZOPYRAN DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
The present invention provides eye drops in the form of a solution comprising: in an aqueous medium, (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazole-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran or a pharmaceutically acceptable salt thereof; propylene gl...
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Sprache: | eng ; fre ; kor |
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Zusammenfassung: | The present invention provides eye drops in the form of a solution comprising: in an aqueous medium, (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazole-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran or a pharmaceutically acceptable salt thereof; propylene glycol as a stabilizer; and a pH adjusting agent, wherein the eye drops have a pH of 4.0 to 5.0. The eye drops of the present invention can contain (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazole-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran or a pharmaceutically acceptable salt thereof at a high concentration, and also the eye drops have excellent stability. In addition, the medicament for preventing or treating macular degeneration, according to the present invention, can be stored for a long period of time.
La présente invention concerne des gouttes pour les yeux sous la forme d'une solution comprenant : dans un milieu aqueux, du (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazole-2-ylméthyl)amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane ou un sel pharmaceutiquement acceptable correspondant ; du propylène glycol en tant que stabilisant ; et un agent de régulation du pH, le pH des gouttes pour les yeux étant compris entre 4,0 et 5,0. Les gouttes pour les yeux selon la présente invention peuvent contenir du (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazole-2-ylméthyl)amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane ou un sel pharmaceutiquement acceptable correspondant en concentration élevée. Les gouttes pour les yeux présentent également une excellente stabilité. De plus, le médicament pour prévenir ou traiter la dégénérescence maculaire selon la présente invention peut être stocké pendant longtemps.
본 발명은 수성 매질 중에 (2R,3R,4S)-6-아미노-4-[N-(4-클로로페닐)-N-(1H-이미다졸-2-일메틸)아미노]-3-하이드록시-2-메틸-2-다이메톡시메틸-3,4-다이하이드로-2H-1-벤조피란 또는 이의 약학적으로 허용가능한 염; 안정화제로서 프로필렌글리콜; 및 pH 조절제를 포함하고, 4.0 ∼ 5.0의 pH를 갖는, 용액 형태의 점안제를 제공한다. 본 발명의 점안제는 (2R,3R,4S)-6-아미노-4-[N-(4-클로로페닐)-N-(1H-이미다졸-2-일메틸)아미노]-3-하이드록시-2-메틸-2-다이메톡시메틸-3,4-다이하이드로-2H-1-벤조피란 또는 이의 약학적으로 허용가능한 염을 고농도로 함유할 수 있을 뿐만 아니라 우수한 안정성을 갖는다. 또한, 본 발명에 따른 황반변성의 예방 또는 치료를 위한 의약품은 장기간 동안 보관이 가능하다. |
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