ANTI-PD-1/ANTI-VEGF NATURAL ANTIBODY STRUCTURE-LIKE HETERODIMERIC FORM BISPECIFIC ANTIBODY AND PREPARATION THEREOF

An anti-PD-1/anti-VEGF natural antibody structure-like heterodimeric form bispecific antibody and the preparation thereof. Provided are a highly stable, heterodimeric form anti-PD-1/anti-VEGF bispecific antibody having natural IgG characteristics and free of mismatched heavy and light chains and a p...

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Bibliographische Detailangaben
Hauptverfasser:	YANG, Yaping, SONG, Nanmeng, XIAO, Wenchu, LI, Zhenlei, GU, Mingyue, ZHAN, Chunguang, LIU, Jiawang, ZHANG, Lina, KIM, Maengsup
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An anti-PD-1/anti-VEGF natural antibody structure-like heterodimeric form bispecific antibody and the preparation thereof. Provided are a highly stable, heterodimeric form anti-PD-1/anti-VEGF bispecific antibody having natural IgG characteristics and free of mismatched heavy and light chains and a preparation method for the antibody. The bispecific antibody is capable of simultaneously binding with two target molecules and provides improved efficacy in treating a complicated disease. L'invention concerne un anticorps bispécifique à forme hétérodimère de type similaire à une structure d'anticorps naturel anti-PD-1/anti-VEGF et une préparation associée. L'invention concerne un anticorps bispécifique anti-PD-1/anti-VEGF à forme hétérodimère hautement stable ayant des caractéristiques d'IgG naturel et exempt de chaînes lourdes et légères non appariées ainsi qu'un procédé de préparation de l'anticorps. L'anticorps bispécifique est capable de se lier simultanément à deux molécules cibles et fournit une efficacité a