CRYSTALLINE FORMS OF 4-(((3AR,5AR,5BR,7AR,9S,11AR,11BR,13AS)-3A-((R)-2-((4-CHLOROBENZYL)(2-(DIMETHYLAMINO)ETHYL)AMINO)-1-HYDROXYETHYL)-1-ISOPROPYL-5A,5B,8,8,11A-PENTAMETHYL-2-OXO-3,3A,4,5,5A,5B,6,7,7A,8,9,10,11,11A,11B,12,13,13A-OCTADECAHYDRO-2H-CYCLOPENTA[A]CHRYSEN-9-YL)OXY)-2,2-DIMETHYL-4-OXOBUTANOIC ACID

CRYSTALLINE FORMS OF 4-(((3AR,5AR,5BR,7AR,9S,11AR,11BR,13AS)-3A-((R)-2-((4-CHLOROBENZYL)(2-(DIMETHYLAMINO)ETHYL)AMINO)-1-HYDROXYETHYL)-1-ISOPROPYL-5A,5B,8,8,11A-PENTAMETHYL-2-OXO-3,3A,4,5,5A,5B,6,7,7A,8,9,10,11,11A,11B,12,13,13A-OCTADECAHYDRO-2H-CYCLOPENTA[A]CHRYSEN-9-YL)OXY)-2,2-DIMETHYL-4-OXOBUTANOIC ACID

The present invention discloses certain sulphonic acid salts of 4-(((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[...

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Bibliographische Detailangaben
Hauptverfasser: WOODS, Martin, STRACHAN, John Bryce, MANLEY, David William, HERKOMMER, Daniel Tobias, DERDOUR, Lotfi
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention discloses certain sulphonic acid salts of 4-(((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid or a solvate thereof. Also described are synthetic routes and crystalline forms. 26 La présente invention concerne certains sels d'acide sulfonique d'acide 4-(((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(diméthylamino)éthyl)amino)-1-hydroxyéthyl)-1-isopropyl-5a,5b,8,8,11a-pentaméthyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadécahydro-2H-cyclopenta[a]chrysén-9-yl)oxy)-2,2-diméthyl-4-oxobutanoïque ou un solvate de ceux-ci. L'invention concerne également des voies synthétiques et des formes cristallines.