RECOMBINANT VACCINIA VIRUS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a recombinant vaccinia virus comprising a gene encoding sPD-1 or hyaluronidase and to a pharmaceutical composition comprising the same. The recombinant vaccinia virus comprising a cancer therapy gene and having suppressed expression of K3L, TK, or VGF gene of the vac...

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Bibliographische Detailangaben
Hauptverfasser:	HONG, Soonoh, HONG, Jieun, KIM, Sujeong, KIM, Minjung, LEE, Eunjin, SHIN, Jaeil, LEE, Soondong, KIM, Joonsung, LEE, Hyesun, KANG, Haesu, CHOI, Heonsik, CHOI, Hwanjun
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a recombinant vaccinia virus comprising a gene encoding sPD-1 or hyaluronidase and to a pharmaceutical composition comprising the same. The recombinant vaccinia virus comprising a cancer therapy gene and having suppressed expression of K3L, TK, or VGF gene of the vaccinia virus according to the present invention has an excellent anti-tumor effect. Therefore, the recombinant vaccinia virus of the present invention can be advantageously used in cancer treatment. La présente invention se rapporte à un virus de la vaccine recombinant comprenant un gène codant pour sPD-1 ou une hyaluronidase et à une composition pharmaceutique le comprenant. Le virus de la vaccine recombinant comprenant un gène de cancérothérapie et ayant supprimé l'expression du gène K3L, TK ou VGF du virus de la vaccine selon la présente invention présente un excellent effet antitumoral. Le virus de la vaccine recombinant selon la présente invention peut donc être utilisé avantageusement pour le traitement du cancer. 본 발명은 sPD-1 또는 히알루로니다아제를 암호화하는 유전자를 포함하는 재조합 백시니아 바이러스 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명에 따른 암 치료 유전자를 포함하고, 백시니아 바이러스의 K3L, TK 또는 VGF 유전자의 발현이 억제된 재조합 백시니아 바이러스는 항종양 효과가 우수하다. 따라서, 본 발명의 재조합 백시니아 바이러스는 암을 치료하는 데 유용하게 사용될 수 있다.