METHOD FOR SYNTHESIS OF LOBARIC ACID AND ANALOG THEREOF

In the present invention, lobaric acid and four analogs thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, can be synthesized simply, economically, and effectively in a chemical synthesis method. La...

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Bibliographische Detailangaben
Hauptverfasser:	YIM, Joung Han, KIM, Tai Kyoung, YOUN, Ui Joung, LEE, Hong Kum, HAN, Se Jong, KIM, Il-Chan, YEO, Kwon Joo, LEE, Jun Hyuck
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	In the present invention, lobaric acid and four analogs thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, can be synthesized simply, economically, and effectively in a chemical synthesis method. La présente invention concerne un procédé de synthèse chimique d'un acide lobarique et quatre analogues de celui-ci, qui sont cinq métabolites de lichen phénolique isolés à partir d'un extrait de lichen antarctique de Stereocaulon alpinum et inhibent de manière sélective PTP1B ; le procédé selon l'invention est un procédé simple, économique et efficace. 본 발명은 남극 지의류인 스테레오카울론 알피넘(Stereocaulon alpinum) 추출물에서 분리된 5개의 페놀성 지의류 대사산물로서, PTP1B을 선택적으로 저해하는 로바릭산의 4가지 유사체를 간단하고 경제적이며 효율적인 화학합성방법으로 합성할 수 있다.