PROCESSES FOR THE STEREOSELECTIVE PREPARATION OF BACE INHIBITORS

PROCESSES FOR THE STEREOSELECTIVE PREPARATION OF BACE INHIBITORS

The present application relates to processes for the stereoselective preparation of dihydroimidazole ring systems. Compounds prepared according to the disclosed processes are useful in treating at least one condition associated with inhibitition of the deposition of amyloid ß peptide (Aß) and portio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WOODWARD, Robert Leslie, GOTTSCHLING, Stephen, MORRISON, James Alexander, INGLESBY, Phillip Anthony
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present application relates to processes for the stereoselective preparation of dihydroimidazole ring systems. Compounds prepared according to the disclosed processes are useful in treating at least one condition associated with inhibitition of the deposition of amyloid ß peptide (Aß) and portions thereof by inhibiting or the beta site APP Cleaving Enzyme (BACE). La présente invention concerne des procédés de préparation stéréosélective de systèmes cycliques dihydroimidazole. Les composés préparés selon les procédés décrits sont utiles dans le traitement d'au moins un état associé à l'inhibition du dépôt du peptide β-amyloïde (Aβ) et des parties de celui-ci par inhibition de l'enzyme de clivage APP du site bêta (BACE).