ANTIBODIES BINDING CTLA-4 AND USES THEREOF

Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided. L'invention concerne des anticorps...

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Hauptverfasser: DRABEK, Dubravka, SHEN, Yuqiang, HE, Yun, VAN HAPEREN, Marinus (Rien), GAN, Xin, RONG, Yiping, ZHAO, Jiuqiao, JANSSENS, Rick, GROSVELD, Frank
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creator DRABEK, Dubravka
SHEN, Yuqiang
HE, Yun
VAN HAPEREN, Marinus (Rien)
GAN, Xin
RONG, Yiping
ZHAO, Jiuqiao
JANSSENS, Rick
GROSVELD, Frank
description Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided. L'invention concerne des anticorps monoclonaux isolés, comprenant un domaine de liaison à CD152, les anticorps Se liant spécifiquement à CD152 humain. L'invention concerne également des procédés de fabrication et d'utilisation des anticorps pour traiter des maladies comprenant des cancers et des maladies auto-immunes.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANTIBODIES BINDING CTLA-4 AND USES THEREOF
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