CRYSTALLINE POLYMORPHS OF ABEMACICLIB

The present disclosure provides novel polymorphs of abemaciclib, solid dispersions of abemaciclib with pharmaceutical excipients, and processes for the preparation thereof. The disclosure further provides methods for preparing crystalline abemaciclib form I, amorphous abemaciclib, and methods for sy...

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Bibliographische Detailangaben
Hauptverfasser:	INDUKURI, Anjaneyaraju, BATHARAJU, Ramesh, JETTI, Ramakoteswara Rao, JEBARAJ, Rathinapandian, CHANDUPATLA, Shivakumar, SRINIVASARAO, Attanti Veera Venkata, BOMMAREDDY, Aggi Ramireddy, KUNAMNENI, Sunil
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present disclosure provides novel polymorphs of abemaciclib, solid dispersions of abemaciclib with pharmaceutical excipients, and processes for the preparation thereof. The disclosure further provides methods for preparing crystalline abemaciclib form I, amorphous abemaciclib, and methods for synthesizing abemaciclib. La présente invention concerne de nouveaux polymorphes d'abémaciclib, des dispersions solides d'abémaciclib avec des excipients pharmaceutiques, et des procédés pour leur préparation. L'invention concerne en outre des procédés de préparation de la forme I d'abémaciclib cristallin, de l'abémaciclib amorphe et des procédés de synthèse de l'abémaciclib.