PROCESSES FOR THE PREPARATION OF CIS-4 [2-{(3S.4R)-3-FLUOROOXAN-4-YL]AMINO)-8-(2,4,6-TRICHLOROANILINO)-9H-PURIN-9-YL]-1-METHYLCYCLOHEXANE-1-C ARBOXAMIDE

PROCESSES FOR THE PREPARATION OF CIS-4 [2-{(3S.4R)-3-FLUOROOXAN-4-YL]AMINO)-8-(2,4,6-TRICHLOROANILINO)-9H-PURIN-9-YL]-1-METHYLCYCLOHEXANE-1-C ARBOXAMIDE

Provided herein are processes for the preparation of cis-4-[2-{[(3S,4R) -3-fluorooxan-4-yl]amino} -8-(2,4,6-trichloroanilino)-9H-purin-9- yl]-l -methylcyclohexane-1 - carboxamide, alternatively named (ls,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8- ((2,4,6-trichlorophenyl)amino)-9H-...

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Bibliographische Detailangaben
Hauptverfasser: GEHERTY, Maryll, CHEN, Zheng, LU, Xiaoling, KREILEIN, Matthew, ZOU, Nanfei
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Provided herein are processes for the preparation of cis-4-[2-{[(3S,4R) -3-fluorooxan-4-yl]amino} -8-(2,4,6-trichloroanilino)-9H-purin-9- yl]-l -methylcyclohexane-1 - carboxamide, alternatively named (ls,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8- ((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-l-methylcyclohexane-l- carboxamide, or a salt, solvate, hydrate, or isotopologue thereof. La présente invention concerne des procédés de préparation de cis-4-[2-{[(3S,4R) -3-fluorooxan-4-yl]amino} -8-(2,4,6-trichloroanilino)-9H-purin-9- yl]-l -méthylcyclohexane-1 - carboxamide, en variante nommée (ls,4s)-4-(2-(((3S,4R)-3-fluorotétrahydro-2H-pyran-4-yl)amino)-8- ((2,4,6-trichlorophényl)amino)-9H-purin-9-yl)-l-méthylcyclohexane-l- carboxamide, ou un sel, un solvate, un hydrate ou un isotopologue de celle-ci.