COMPOSITION COMPRISING MIQUELIANIN AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING TH2-MEDIATED IMMUNE DISEASE

The present invention relates to a composition comprising miquelianin as an effective ingredient for preventing, alleviating, or treating Th2-mediated immune diseases. A composition according to the present invention was found to have an excellent anti-allergic effect. In greater detail, miquelianin...

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Bibliographische Detailangaben
Hauptverfasser:	SHIN, Hee Soon, EOM, Ji Eun, JUNG, Sun Young, PARK, So-Lim, CHOI, Dae Woon, SEO, Dong-Ho, PIL, Gam Bang, SHIN, Dong Uk, SHON, Dong-Hwa, LEE, So-Young, YEON, Sung Hum, SON, Rak Ho, NAM, Young-Do
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a composition comprising miquelianin as an effective ingredient for preventing, alleviating, or treating Th2-mediated immune diseases. A composition according to the present invention was found to have an excellent anti-allergic effect. In greater detail, miquelianin was identified to restrain the generation of interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5), and/or interleukin-13 (IL-13) as tested for anti-allergic effect in vivo and ex vivo. Also, miquelianin was found to have the effect of producing IgE and preventing T cell proliferation. Therefore, the composition according to the present invention is expected to find useful applications in the development of a therapeutic agent, a health functional food, and a cosmetic product for prevention, alleviation, or treatment of Th2-mediated immune diseases. La présente invention concerne une composition comprenant de la miquélianine en tant que principe actif pour prévenir, soulager ou traiter des maladies immunitaires médiées par Th2. Une composition selon la présente invention s'est avérée présenter un excellent effet antiallergique. Plus en détail, la miquélianine a été identifiée pour restreindre la génération d'interleukine-2 (IL-2), d'interleukine-4 (IL-4), d'interleukine-5 (IL-5), et/ou d'interleukine-13 (IL-13) alors que l'on testait son effet anti-allergique in vivo et ex vivo. En outre, la miquélianine s'est avérée avoir l'effet de produire des IgE et d'empêcher la prolifération des lymphocytes T. Par conséquent, la composition selon la présente invention est censée trouver des applications utiles dans la mise au point d'un agent thérapeutique, d'un aliment fonctionnel de santé, et d'un produit cosmétique pour la prévention, le soulagement ou le traitement de maladies immunitaires médiées par Th2. 본 발명은 미퀠리아닌을 유효성분으로 포함하는 Th2-매개 면역질환의 예방, 개선, 또는 치료용 조성물에 관한 것으로서, 본 발명에 따른 조성물은 항알레르기 효과가 뛰어난 것을 확인하였다. 보다 구체적으로, In vivo 및 ex vivo 에서 미퀠리아닌의 항알레르기 효과를 실험한 결과, 인터루킨-2 (IL-2) 인터루킨-4 (IL-4), 인터루킨-5 (IL-5), 및/또는 인터루킨-13 (IL-13)의 생성이 억제되는 것을 확인하였으며, IgE의 생성 및 T 세포 증식억제 효과도 있음을 확인하였다. 따라서 본 발명에 따른 조성물은 Th2-매개 면역질환의 예방, 개선, 또는 치료를 위한 치료제, 건강기능성 식품, 및 화장품의 개발에 유용하게 이용될 수 있을 것으로 기대된다.