AZOBENZENE POLYMER NETWORK, AND USES THEREOF FOR BIOFILM REMOVAL AND CONTROL OVER CELL ATTACHMENT

Disclosed methods include formulating azobenzene-based polymer networks to induce a modulus change in a highly crosslinked polymer, in vivo, with no external heat requirement and using a benign light as the source of stimuli. A modulus change can be achieved via a coating on the substrate and within...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	NAIR, Devatha, SHAHEEN, Sean, MCLEOD, Robert, KEHE, Gannon, SCHURR, Michael, NAGARAJ, Ram
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ADHESIVES AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMICAL PAINT OR INK REMOVERS CHEMISTRY COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS CORRECTING FLUIDS DENTISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR DYES FILLING PASTES GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE INKS MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS ORGANIC MACROMOLECULAR COMPOUNDS PAINTS PASTES OR SOLIDS FOR COLOURING OR PRINTING POLISHES THEIR PREPARATION OR CHEMICAL WORKING-UP USE OF MATERIALS THEREFOR WOODSTAINS WORKING-UP
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Disclosed methods include formulating azobenzene-based polymer networks to induce a modulus change in a highly crosslinked polymer, in vivo, with no external heat requirement and using a benign light as the source of stimuli. A modulus change can be achieved via a coating on the substrate and within the bulk of the substrate via photoexposure. The azobenzene-based polymer network can be formed as a coating or in the bulk of a material from either a glassy composition comprising methyl methacrylate (MMA), poly(methyl methacrylate) (PMMA), and triethylene glycol dimethacrylate (TEGDMA) or a soft material comprising of long-chain difunctional acrylates. The disclosed technology also includes methods of biofilm disruption and removal from the surface of a substrate, and includes methods of inhibiting biofilm growth and cell attachment to a substrate. L'invention concerne des procédés qui comprennent la formulation de réseaux polymères à base d'azobenzène pour induire un changement de module dans un polymère hautement réticulé, in vivo, sans exigence de chaleur externe et utilisation d'une lumière bénigne comme source de stimulus. Un changement de module peut être obtenu par l'intermédiaire d'un revêtement sur le substrat et à l'intérieur de la masse du substrat par photo-exposition. Le réseau polymère à base d'azobenzène peut être formé en tant que revêtement ou dans la masse d'un matériau à partir d'une composition vitreuse comprenant du méthacrylate de méthyle (MMA), du poly(méthacrylate de méthyle) (PMMA), et du diméthacrylate de triéthylène glycol (TEGDMA) ou un matériau souple comprenant des acrylates difonctionnels à longue chaîne. La technologie selon l'invention comprend également des procédés de rupture et d'élimination de biofilm de la surface d'un substrat, et comprend des procédés d'inhibition de la croissance de biofilm et de la fixation de cellules à un substrat.