MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatme...

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Hauptverfasser:	DAI, Yujia, KLING, Andreas, DOHERTY, George, POHLKI, Frauke, SULLIVAN, Gerard, LAI, Chunqui, SOUERS, Andrew, TESKE, Jesse, JI, Cheng, JANTOS, Katja, YU, Yiyun, ZHU, Guidong, PENNING, Thomas, JUDD, Andrew, KUNZER, Aaron, RISI, Roberto, WENDT, Michael, BRAJE, Wilfried, TAO, Zhi-Fu, GUILLIER, Fabrice, BRADY, Patrick, WANG, Xilu, GONG, Jane, MASTRACCHIO, Anthony, SONG, Xiaohong, POTIN, Dominique
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I). La présente invention concerne des composés répondant à la formule (I), dans laquelle A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, et Y adoptent l'une quelconque des valeurs définies dans la description, et des sels pharmaceutiquement acceptables associés, qui sont utiles en tant qu'agents dans le traitement de maladies et d'états pathologiques, notamment le cancer. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés répondant à la formule (I).