COMPOSITIONS AND METHODS FOR ENHANCING MATURATION STATES OF HEALTHY AND DISEASED CARDIOMYOCYTES

The methods and compositions as disclosed herein describe the making of mature stem cell- derived cardiomyocytes for applications such as disease modeling, cardiotoxicity screening, drug screening and identification, among other uses. The methods involve physical and biochemical cues that promote a transition of stem cell-derived cardiomyocytes from a fetal phenotype to a more mature phenotype that more closely resembles that of adult cardiomyocytes. L'invention concerne des procédés et des compositions utilisés pour la production de cardiomyocytes dérivés de cellules souches matures pour des applications telles que la modélisation de maladies, le dépistage d'une cardiotoxicité, l'identification et le criblage de médicaments, entre autres utilisations. Les procédés impliquent des indices physiques et biochimiques qui favorisent la transition de cardiomyocytes dérivés de cellules souches d'un phénotype fœtal à un phénotype plus mature qui ressemble davantage à celui des cardiomyocytes adultes.