PHARMACEUTICAL COMPOSITION COMPRISING ABIRATERONE ACETATE AND DARULOTAMIDE

Disclosed herein are pharmaceutical compositions comprising Abiraterone acetate and Darolutamide, which are useful in the treatment of a type of prostate cancer. The pharmaceutical composition possesses increased in- vitro permeability both in fasted and fed state which allows significant dose reduc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GLAVINAS, Hristos, UJHELYI, Andrea, SZABÓNÉ ORDASI, Betti, JORDÁN, Tamás, SOLYMOSI, Tamás, ERDOSI, Nikoletta
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	Disclosed herein are pharmaceutical compositions comprising Abiraterone acetate and Darolutamide, which are useful in the treatment of a type of prostate cancer. The pharmaceutical composition possesses increased in- vitro permeability both in fasted and fed state which allows significant dose reduction and the abandoning of the requirement of taking the drugs on an empty stomach. Further disclosed are methods of formulating and manufacturing the pharmaceutical composition, its uses and methods of treatment using the pharmaceutical composition. L'invention concerne des compositions pharmaceutiques qui comportent de l'acétate d'abiratérone et du darolutamide et qui sont utilisables dans le traitement d'un type de cancer de la prostate. La composition pharmaceutique possède une perméabilité in vitro augmentée, aussi bien à jeun qu'après une prise d'aliments, ce qui permet une diminution significative de la dose et l'abandon de l'exigence d'une prise de médicaments à jeun. L'invention concerne en outre des procédés de préparation et de fabrication de la composition pharmaceutique, ses utilisations, ainsi que des méthodes de traitement utilisant la composition pharmaceutique.