NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS

The present invention discloses compounds according to Formula (I) Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (SIP) receptor, methods for their production, pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser:	JANSEN, Koen, PALISSE, Adeline, EL BKASSINY, Sandy, ALLART, Brigitte, DUTHION, Béranger, MAMMOLITI, Oscar, TRICARICO, Giovanni, BREBION, Franck Laurent, JAUNET, Alexis, MENET, Christel
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention discloses compounds according to Formula (I) Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (SIP) receptor, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, inflammatory diseases, respiratory diseases, autoimmune diseases, metabolic diseases, cardiovascular diseases, and/or proliferative diseases by administering the compound of the invention. La présente invention concerne des composés selon la formule (I), dans laquelle R1, R2, L, A1, A2, A3, Cy et l'indice n sont tels que définis dans la description. La présente invention concerne des composés antagonistes du récepteur de sphingosine 1-phosphate (SIP), des procédés de production de ces composés, des compositions pharmaceutiques les comprenant, ainsi que des méthodes de traitement utilisant ces composés pour la prophylaxie et/ou le traitement de maladies impliquant des maladies fibrotiques, des maladies inflammatoires, des maladies respiratoires, des maladies auto-immunes, des maladies métaboliques, des maladies cardiovasculaires et/ou des maladies prolifératives par l'administration du composé selon l'invention.