NOVEL TREATMENTS

The present invention is based on the finding that the essential neural protein, neurochondrin (NCDN), interacts with the Survival Motor Neurone (SMN) protein. In neurodegenerative disorders, novel interactions such as this provide new insights into disease pathology and/or additional or alternate t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	THOMPSON, Luke William, SHIRRAN, Sally Lorna, MORRISON, Kimberley Dawn, BOTTING, Catherine Helen, SLEEMAN, Judith Elizabeth
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention is based on the finding that the essential neural protein, neurochondrin (NCDN), interacts with the Survival Motor Neurone (SMN) protein. In neurodegenerative disorders, novel interactions such as this provide new insights into disease pathology and/or additional or alternate therapeutic options. Thus the disclosure provides neurochondrin (NCDN) modulators for use in the treatment and/or prevention of a neurodegenerative disorder. La présente invention est basée sur la découverte selon laquelle la protéine neuronale essentielle, la neurochondrine (NCDN), interagit avec la protéine de survie du motoneurone (SMN). Dans les troubles neurodégénératifs, de nouvelles interactions comme celle-ci fournissent de nouvelles connaissances associées à une pathologie de maladie et/ou des options thérapeutiques supplémentaires ou alternatives. Ainsi, l'invention concerne des modulateurs de la neurochondrine (NCDN) destinés à être utilisés pour le traitement d'un trouble neurodégénératif et/ou pour la prévention de ce dernier.