CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS
The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z...
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creator | AXTEN, Jeffrey Michael KALITA, Biswajit EVANS, Karen Anderson RALPH, Jeffrey M DEMARTINO, Michael P |
description | The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85', and z86' are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
L'invention concerne des dérivés de cycloalcanes pontés substitués. L'invention concerne particulièrement des composés de formule (IIIQ) : dans laquelle X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85' et z86' sont tels que définis dans la description ; ou leurs sels. Les composés selon l'invention sont des inhibiteurs de la voie ATF4. Par conséquent, l'invention concerne également des compositions pharmaceutiques comprenant un composé selon l'invention. L'invention concerne enfin des procédés d'inhibition de la voie ATF4 et le traitement de troubles associés, au moyen d'un composé de l'invention ou d'une composition pharmaceutique comprenant un composé de l'invention. |
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L'invention concerne des dérivés de cycloalcanes pontés substitués. L'invention concerne particulièrement des composés de formule (IIIQ) : dans laquelle X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85' et z86' sont tels que définis dans la description ; ou leurs sels. Les composés selon l'invention sont des inhibiteurs de la voie ATF4. Par conséquent, l'invention concerne également des compositions pharmaceutiques comprenant un composé selon l'invention. L'invention concerne enfin des procédés d'inhibition de la voie ATF4 et le traitement de troubles associés, au moyen d'un composé de l'invention ou d'une composition pharmaceutique comprenant un composé de l'invention.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181213&DB=EPODOC&CC=WO&NR=2018225093A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181213&DB=EPODOC&CC=WO&NR=2018225093A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AXTEN, Jeffrey Michael</creatorcontrib><creatorcontrib>KALITA, Biswajit</creatorcontrib><creatorcontrib>EVANS, Karen Anderson</creatorcontrib><creatorcontrib>RALPH, Jeffrey M</creatorcontrib><creatorcontrib>DEMARTINO, Michael P</creatorcontrib><title>CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS</title><description>The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85', and z86' are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
L'invention concerne des dérivés de cycloalcanes pontés substitués. L'invention concerne particulièrement des composés de formule (IIIQ) : dans laquelle X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85' et z86' sont tels que définis dans la description ; ou leurs sels. Les composés selon l'invention sont des inhibiteurs de la voie ATF4. Par conséquent, l'invention concerne également des compositions pharmaceutiques comprenant un composé selon l'invention. L'invention concerne enfin des procédés d'inhibition de la voie ATF4 et le traitement de troubles associés, au moyen d'un composé de l'invention ou d'une composition pharmaceutique comprenant un composé de l'invention.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB19nD19XR29FFw9vcN8A_1cwlWcASiEDcThQDHEI9wx0gFTz8PTyfPEP-gYB4G1rTEnOJUXijNzaDs5hri7KGbWpAfn1pckJicmpdaEh_ub2RgaGFkZGpgaexoaEycKgBGqiZO</recordid><startdate>20181213</startdate><enddate>20181213</enddate><creator>AXTEN, Jeffrey Michael</creator><creator>KALITA, Biswajit</creator><creator>EVANS, Karen Anderson</creator><creator>RALPH, Jeffrey M</creator><creator>DEMARTINO, Michael P</creator><scope>EVB</scope></search><sort><creationdate>20181213</creationdate><title>CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS</title><author>AXTEN, Jeffrey Michael ; KALITA, Biswajit ; EVANS, Karen Anderson ; RALPH, Jeffrey M ; DEMARTINO, Michael P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2018225093A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2018</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>AXTEN, Jeffrey Michael</creatorcontrib><creatorcontrib>KALITA, Biswajit</creatorcontrib><creatorcontrib>EVANS, Karen Anderson</creatorcontrib><creatorcontrib>RALPH, Jeffrey M</creatorcontrib><creatorcontrib>DEMARTINO, Michael P</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>AXTEN, Jeffrey Michael</au><au>KALITA, Biswajit</au><au>EVANS, Karen Anderson</au><au>RALPH, Jeffrey M</au><au>DEMARTINO, Michael P</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS</title><date>2018-12-13</date><risdate>2018</risdate><abstract>The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85', and z86' are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
L'invention concerne des dérivés de cycloalcanes pontés substitués. L'invention concerne particulièrement des composés de formule (IIIQ) : dans laquelle X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85' et z86' sont tels que définis dans la description ; ou leurs sels. Les composés selon l'invention sont des inhibiteurs de la voie ATF4. Par conséquent, l'invention concerne également des compositions pharmaceutiques comprenant un composé selon l'invention. L'invention concerne enfin des procédés d'inhibition de la voie ATF4 et le traitement de troubles associés, au moyen d'un composé de l'invention ou d'une composition pharmaceutique comprenant un composé de l'invention.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS |
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