CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS

The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85', and z86' are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. L'invention concerne des dérivés de cycloalcanes pontés substitués. L'invention concerne particulièrement des composés de formule (IIIQ) : dans laquelle X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85' et z86' sont tels que définis dans la description ; ou leurs sels. Les composés selon l'invention sont des inhibiteurs de la voie ATF4. Par conséquent, l'invention concerne également des compositions pharmaceutiques comprenant un composé selon l'invention. L'invention concerne enfin des procédés d'inhibition de la voie ATF4 et le traitement de troubles associés, au moyen d'un composé de l'invention ou d'une composition pharmaceutique comprenant un composé de l'invention.