COMPOSITION FOR EVALUATING ACTIVITY OF DRUG METABOLIZING ENZYME OF NEW DRUG CANDIDATE, AND METHOD FOR EVALUATING ACTIVITY OF DRUG METABOLIZING ENZYME BY USING SAME

The present invention relates to a composition containing a cocktail set for evaluating the activity of a drug metabolizing enzyme of a novel drug candidate, and a method for evaluating the activity of a drug metabolizing enzyme of a novel drug candidate by using the same. When the composition and t...

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Bibliographische Detailangaben
Hauptverfasser:	LIU, Kwang Hyeon, LEE, Tae Ho, JI, Hyeon Kyeong
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a composition containing a cocktail set for evaluating the activity of a drug metabolizing enzyme of a novel drug candidate, and a method for evaluating the activity of a drug metabolizing enzyme of a novel drug candidate by using the same. When the composition and the method are used, the activity of 10 types of cytochrome P450 isozymes can be simultaneously evaluated such that effects on the activity of a drug metabolizing enzyme of a novel drug candidate can be rapidly measured, thereby enabling drug interactions in the body to be predicted. La présente invention concerne une composition contenant un ensemble cocktail permettant l'évaluation de l'activité d'une enzyme de métabolisation de médicament d'un nouveau médicament candidat, ainsi qu'un procédé d'évaluation de l'activité d'une enzyme de métabolisation de médicament d'un nouveau médicament candidat à l'aide de cette dernière. Lorsque la composition et le procédé sont utilisés, l'activité de 10 types d'isozymes de cytochrome P450 peut être simultanément évaluée de telle sorte que des effets sur l'activité d'une enzyme de métabolisation de médicament d'un nouveau médicament candidat peuvent être rapidement mesurés, ce qui permet de prédire des interactions de médicament dans le corps. 본 발명은 신약 후보물질의 약물 대사 효소 활성을 평가하기 위한 칵테일 세트를 포함하는 조성물 및 이를 이용한 신약 후보물질의 약물 대사 효소 활성 평가 방법에 관한 것으로, 상기 조성물 및 방법을 이용하면 시토크롬 P450 동효소 10종의 활성을 동시에 평가하여 신약 후보물질이 약물 대사 효소의 활성에 미치는 영향을 신속히 신속히 측정할 수 있으며, 따라서 체내에서의 약물 상호 작용을 예측할 수 있다.