SMALL MOLECULE INHIBITORS OF BCL-2-ASSOCIATED DEATH PROMOTER (BAD) PHOSPHORYLATION

The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast canc...

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Bibliographische Detailangaben
Hauptverfasser:	PANDEY, Vijay Kumar, KANCHUGARAKOPPAL SUBBEGOWDA, Rangappa, VENKATACHALAIAH, Srinivasa, RANGAPPA, Shobith, CHAKRABHAVI DHANANJAYA, Mohan, LOBIE, Peter Edward, SALUNDI, Bassappa
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer. La présente invention concerne des composés de formule générale (I), dans laquelle R1, n, R2a, R2b et R3 sont tels que définis dans la description. Les composés de l'invention sont des inhibiteurs de phosphorylation de promoteur de mort associé à Bcl-2 (BAD) et ont une activité anti-apoptotique et sont utiles dans le traitement du cancer, notamment le cancer du sein, le cancer de l'endomètre, le cancer de l'ovaire, le cancer du foie, le cancer du côlon, le cancer de la prostate ou le cancer du pancréas.