COMPOSITIONS, PACKAGED PHARMACEUTICALS, AND METHODS OF USING POSACONAZOLE FOR THE SENSITIZATION OF RESISTANT TUMORS

Compositions, packaged pharmaceuticals, and methods of treatment by the sensitization of resistant tumors are provided. The compositions comprise posaconazole and a chemotherapeutic agent. Tumor cells in mammalian subjects treated with posaconazole are sensitized to the effects of the chemotherapeut...

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Bibliographische Detailangaben
1. Verfasser:	BHAGWANDIN, Vikash J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING
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Beschreibung
Zusammenfassung:	Compositions, packaged pharmaceuticals, and methods of treatment by the sensitization of resistant tumors are provided. The compositions comprise posaconazole and a chemotherapeutic agent. Tumor cells in mammalian subjects treated with posaconazole are sensitized to the effects of the chemotherapeutic agent, thus increasing the therapeutic index of the agent and reducing toxicity to the subject. La présente invention concerne des compositions, des produits pharmaceutiques conditionnés, et des méthodes de traitement par la sensibilisation de tumeurs résistantes. Les compositions comprennent du posaconazole et un agent chimiothérapeutique. Les cellules tumorales chez des sujets mammifères traités avec le posaconazole sont sensibilisées aux effets de l'agent chimiothérapique, augmentant ainsi l'indice thérapeutique de l'agent et réduisant également la toxicité pour le sujet.