NERATINIB CRYSTALLINE FORMS AND PROCESS FOR PREPARATION THEREOF

NERATINIB CRYSTALLINE FORMS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to novel crystalline forms of Neratinib and processes for preparation thereof. Neratinib is a tyrosine kinase inhibitor formula (I), having the chemical name (2E)-N-[4-[[3-Chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano- 7-ethoxyquinolin-6-yl]-4-(dimethylamino)but...

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Bibliographische Detailangaben
Hauptverfasser: SHIVDAVKAR, Radhakrishna, SIYAN, Rajinder, BHISE, Nandu, SANPHUI, Palash, SADAPHAL, Vikas, SULAKE, Rohidas, SINGH, Girij
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to novel crystalline forms of Neratinib and processes for preparation thereof. Neratinib is a tyrosine kinase inhibitor formula (I), having the chemical name (2E)-N-[4-[[3-Chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano- 7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide. La présente invention concerne de nouvelles formes cristallines de nératinib et des procédés de préparation correspondants. Le nératinib, selon l'invention, est un inhibiteur de tyrosine kinase de formule (I), portant le nom chimique (2E)-N-[4-[[3-Chloro-4-[(pyridin-2-yl)méthoxy]phényl]amino]-3-cyano-7-éthoxyquinolin-6-yl]-4-(diméthylamino)but-2-énamide.