4-((2-(6-(4-METHYLPIPERAZINE-1-CARBONYL)NAPHTHALEN-2-YL)ETHYL)AMINO)QUINAZOLINE-6-CARBONITRILE SALTS AND PHARMACEUTICAL COMPOSITION

The invention relates to 4-((2-(6-(4-methylpiperazine- 1-carbonyl)naphthalen-2-yl)ethyl)amino)quinazoline-6-carbonitrile salts which exhibit the properties of an inhibitor of cyclin-dependent kinase CDK8/CDK19. The invention also relates to methods for producing same, to pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser:	KOPYLOVA, Olga Viktorovna, ALESHUNIN, Pavel Aleksandrovich, EVSTIGNEEVA, Elena Vladimirovna
Format:	Patent
Sprache:	eng ; fre ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to 4-((2-(6-(4-methylpiperazine- 1-carbonyl)naphthalen-2-yl)ethyl)amino)quinazoline-6-carbonitrile salts which exhibit the properties of an inhibitor of cyclin-dependent kinase CDK8/CDK19. The invention also relates to methods for producing same, to pharmaceutical compositions containing said salts, and to the use of such salts or compositions to treat diseases or disorders. L'invention concerne les sels de 4-((2-(6-(4-méthylpipérazin- 1-carbonyl)naphtalin-2-il)éthyl)amino)quinazolin-6-carbonitryle qui possèdent une capacité d'inhibiteur de kinase cyclo-indépendante CDK8/CDK19. L'invention concerne également des procédés de leur fabrication, des compositions pharmaceutiques comprenant ces sels et l'utilisation de ces sel ou compositions pour traiter des maladies ou de troubles. Изобретение относится к солям 4-((2-(6-(4-метилпиперазин- 1-карбонил)нафталин-2-ил)этил)амино)хиназолин-6-карбонитрила, которые обладают свойствами ингибитора циклинзависимой киназы CDK8/CDK19. Изобретение также относится к способам их получения, фармацевтическим композициям, включающим данные соли, и к применению таких солей или композиций для лечения заболеваний или нарушений.