COMPOSITIONS COMPRISING BIODEGRADABLE COPOLYMERS

A depot system containing at least one antibiotic and a biodegradable poly(ester-anhydride) is provided. The system provides prolonged local release of the antibiotic at the site of injection while maintaining the systemic antibiotic levels at sub-therapeutic concentrations. L'invention concern...

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Bibliographische Detailangaben
Hauptverfasser:	DOMB, Abraham, HAGIGIT, Tal, HANUKA, Ezra, SCHLINGER, Ron, GRISHKO, Michael
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	A depot system containing at least one antibiotic and a biodegradable poly(ester-anhydride) is provided. The system provides prolonged local release of the antibiotic at the site of injection while maintaining the systemic antibiotic levels at sub-therapeutic concentrations. L'invention concerne un système de dépôt contenant au moins un antibiotique et un poly(ester-anhydride) biodégradable. Le système permet une libération locale prolongée de l'antibiotique au niveau du site d'injection tout en maintenant les niveaux d'antibiotiques systémiques à des concentrations sous-thérapeutiques.