ANGIOPOIETIN 2-BASED POLYPEPTIDE INHIBITORS AND METHODS OF USE THEREOF

Described herein is the generation of inhibitory polypeptides based on the Ang2- binding domain (Ang2-BD), but having greater affinity for Tie2 and/or integrin alpha v beta 3 (ανβ3) than the native Ang2-BD. Uses of the generated Ang2-BD variants as cancer and anti- angiogenesis therapeutics are also...

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Bibliographische Detailangaben
Hauptverfasser:	PAPO, Niv, SHLAMKOVICH, Tomer
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein is the generation of inhibitory polypeptides based on the Ang2- binding domain (Ang2-BD), but having greater affinity for Tie2 and/or integrin alpha v beta 3 (ανβ3) than the native Ang2-BD. Uses of the generated Ang2-BD variants as cancer and anti- angiogenesis therapeutics are also described. L'invention concerne la génération de polypeptides inhibiteurs basés sur le domaine de liaison à Ang2 (Ang2-BD), mais ayant une affinité plus importante pour Tie2 et/ou l'intégrine alpha v beta 3 (ανβ3) que l'Ang2-BD natif. L'invention concerne également des utilisations des variants Ang2-BD générés en tant qu'agents thérapeutiques contre le cancer et anti-angiogenèse.