PYRROLOQUINOLIN COMPOUNDS AND METHODS OF USING SAME

Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., p...

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Bibliographische Detailangaben
Hauptverfasser:	MCCAULEY, Erin P, CREWS, Phillip, TENNEY, Karen, VALERIOTE, Frederick A, LORIG-ROACH, Nicholas, LIN, Sheng
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided. Formula (I), (II). L'invention concerne des composés de pyrroloquinoléine de formule (1) ou (II). Dans certains aspects, les composés de pyrroloquinoléine sont thérapeutiques, par exemple, en vue de traiter un trouble de prolifération cellulaire. L'invention concerne également des conjugués qui comprennent les composés de pyrroloquinoléine de la présente invention. L'invention concerne aussi des compositions, par exemple des compositions pharmaceutiques, qui comprennent les composés de pyrroloquinoléine et les conjugués de la présente invention. L'invention concerne en outre des méthodes thérapeutiques impliquant l'administration des composés de pyrroloquinoléine, des conjugués ou des compositions de la présente invention. L'invention concerne aussi des kits qui comprennent les composés de pyrroloquinoléine, les conjugués ou les compositions.