TETRAHYDROPYRAN AND TETRAHYDROTHIOPYRAN METHANONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to tetrahydropyran and tetrahydrothiopyran methanone derivatives having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to th...

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Bibliographische Detailangaben
Hauptverfasser:	ALMANSA-ROSALES, Carmen, GARCIA-LOPEZ, Monica, RODRIGUEZ ESCRICH, Sergio
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to tetrahydropyran and tetrahydrothiopyran methanone derivatives having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. La présente invention concerne des dérivés de méthanone tétrahydropyrane et tétrahydrothiopyrane ayant une double activité pharmacologique à la fois envers le récepteur sigma (σ) et le récepteur µ-opioïde. L'invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant, ainsi que leur utilisation thérapeutique, en particulier pour le traitement de la douleur.