CALCIUM CHANNEL INHIBITORS

The present disclosure describes carbamate analogs of mibefradil, as well as their compositions and methods of use. The compounds block the activity of one or more isoforms of voltage-gated calcium channels and are useful in the treatment of diseases including, e.g., cancer. La présente invention co...

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Bibliographische Detailangaben
Hauptverfasser:	MACDONALD, Timothy, RICHARDSON, Thomas E, HIGGIN, Michelle
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present disclosure describes carbamate analogs of mibefradil, as well as their compositions and methods of use. The compounds block the activity of one or more isoforms of voltage-gated calcium channels and are useful in the treatment of diseases including, e.g., cancer. La présente invention concerne des analogues de carbamate du mibéfradil, ainsi que leurs compositions et leurs méthodes d'utilisation. Les composés bloquent l'activité d'une ou de plusieurs isoformes de canaux calciques dépendants du voltage et sont utiles dans le traitement de maladies comprenant, par exemple, le cancer.