PROTEASOME INHIBITING ß-LACTAM PRODRUGS USEFUL FOR THE TREATMENT OF CANCER AND NEURODEGENERATIVE DISORDERS

The present invention relates generally to proteasome inhibiting β-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/...

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Bibliographische Detailangaben
Hauptverfasser:	AUDRAN, Gérard, SCHULZ, Marvin, OREAL, Henri, SIRI, Didier, SIRI, Anouk, JOLY, Jean-Patrick, SIMON, Philippe Yves-Rémy
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates generally to proteasome inhibiting β-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/or pharmaceutical compositions to treat cancer and neurodegenerative disorders. La présente invention concerne de manière générale des composés de bêta-lactame inhibiteurs de protéasome utiles pour le traitement du cancer et de troubles neurodégénératifs. L'invention concerne également des compositions pharmaceutiques, des formulations à libération prolongée desdits composés et des utilisations médicales desdits composés et/ou compositions pharmaceutiques pour traiter le cancer et les troubles neurodégénératifs.