TACCALONOLIDE MICROTUBULE STABILIZERS

The present disclosure relates to the fields of medicine and pharmaceuticals. In particular, the invention relates to the identification of epoxytaccalonolide microtubule stabilizers for use in inhibiting cell proliferation and disrupting normal cellular microtubule processes leading to cell death....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RISINGER, April, OLA, Antonius, S.M. YEE, Samantha, DU, Lin, PENG, Jiangnan, CICHEWICZ, Robert, LI, Jing, MOOBERRY, Susan
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:The present disclosure relates to the fields of medicine and pharmaceuticals. In particular, the invention relates to the identification of epoxytaccalonolide microtubule stabilizers for use in inhibiting cell proliferation and disrupting normal cellular microtubule processes leading to cell death. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. L'invention concerne les domaines de la médecine et des produits pharmaceutiques. Elle concerne en particulier l'identification de stabilisateurs époxytaccalonolides de microtubules utilisables pour inhiber la prolifération cellulaire et perturber des processus de microtubules cellulaires normaux conduisant à la mort cellulaire...