HETEROCYCLIC AZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES

The invention relates to heterocyclic compounds of formula (I) and (IV) or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the c...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Tiansheng, DENINNO, Michael, FRANTZ, James, LEDFORD, Brian, KOLPAK, Adrienne, COLLIER, Philip, SYKEN, Joshua, KRAUSS, Raul, PEROLA, Emanuele, DAVIES, Robert, GRILLOT, Anne-Laure, RYU, Elizabeth, MAGAVI, Sanjay, LIAO, Yusheng, GOLDMAN, Brian, DOYLE, Elisabeth, TANG, Qing, MALTAIS, Francois
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to heterocyclic compounds of formula (I) and (IV) or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis. L'invention concerne des composés hétérocycliques de formule (I) et (IV) ou des sels pharmaceutiquement acceptables de ceux-ci, utiles en tant que modulateurs de maladies de démyélinisation. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant lesdits composés, ainsi que des méthodes d'utilisation des compositions et des trousses de ces dernières dans le traitement de diverses maladies de démyélinisation et neurodégénératives, y compris la sclérose en plaques.