METHOD FOR ASYMMETRICALLY SYNTHESIZING ASPIDOSPERMA ALKALOID

Disclosed is a method for asymmetrically synthesizing aspidosperma alkaloid. In this method, a key intermediate of formula (4) is obtained by 6 steps of reactions, including [4+2] cycloaddition of the compound of formula (1a) and the compound of formula (1b), decarboxylation, reduction, Wittig reaction, oxidation and Fischer indole rearrangement, and further transformed through several steps to obtain a series of aspidosperma alkaloids. The reaction scheme is shown in scheme (1). The method can start from abundant and readily available compounds of formulas (1a) and (1b), and provides good technical support for subsequent realization of large-scale production of the aspidosperma alkaloid and study of structure-activity relationship. L'invention concerne un procédé de synthèse asymétrique d'alcaloïde d'aspidosperma. Dans ce procédé, un intermédiaire clé de formule (4) est obtenu par 6 étapes de réactions, comprenant la cycloaddition [4+2] du composé de formule (1a) et le composé de formule (1b), la décarboxyla