MET ANTIBODY DRUG CONJUGATES

Provided are antibody-drug conjugates (ADCs) that bind to, and kill MET expressing tumor cells, and that are effective in treating MET expressing cancers. Also provided are novel compounds and methods of conjugating MET antibodies to generate such ADCs. L'invention concerne des conjugués antico...

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Bibliographische Detailangaben
Hauptverfasser:	LI, Renhua, FENG, Yiqing, HIPSKIND, Philip Arthur, WILSON, Takako, LIU, Ling, WROBLESKI, Aaron David
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are antibody-drug conjugates (ADCs) that bind to, and kill MET expressing tumor cells, and that are effective in treating MET expressing cancers. Also provided are novel compounds and methods of conjugating MET antibodies to generate such ADCs. L'invention concerne des conjugués anticorps-médicament (CAM) qui se lient à, et tuent les cellules tumorales exprimant MET, et qui sont efficaces dans le traitement de cancers exprimant MET. L'invention concerne également de nouveaux composés et des procédés de conjugaison d'anticorps anti-MET pour générer de tels CAM.