GLOBULAR STRUCTURE CONTAINING NOVEL PROTEIN TRANSDUCTION DOMAIN
The present invention relates to a globular structure in which novel protein transduction domains are self-assembled. By using the peptide having the amino acid sequence of SEQ ID NO: 1 of the present invention, a globular structure (e.g., liposomes) having improved permeability to cells or the skin...
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Zusammenfassung: | The present invention relates to a globular structure in which novel protein transduction domains are self-assembled. By using the peptide having the amino acid sequence of SEQ ID NO: 1 of the present invention, a globular structure (e.g., liposomes) having improved permeability to cells or the skin can be constructed. In addition, the globular structure (e.g., liposomes) constructed in the present invention can be used to have a sparingly soluble material (skin functional substance or pharmacologically effective substance) loaded therein and to effectively transport the material into the skin or cells.
La présente invention concerne une structure globulaire dans laquelle de nouveaux domaines de transduction de protéine sont auto-assemblés. En utilisant le peptide ayant la séquence d'acides aminés de SEQ ID NO : 1 de la présente invention, une structure globulaire (par exemple, des liposomes) présentant une perméabilité améliorée par rapport aux cellules ou à la peau peut être construite. De plus, la structure globulaire (par exemple, des liposomes) construite dans la présente invention peut être utilisée pour y charger dedans un matériau modérément soluble (substance fonctionnelle de la peau ou substance pharmacologiquement efficace) et pour transporter efficacement le matériau dans la peau ou les cellules.
본 발명은 신규의 프로테인 트랜스덕션 도메인이 자가조립된 구형 구조체에 관한 것으로, 본 발명의 서열번호 1에 기재된 아미노산 서열을 갖는 펩타이드를 이용할 경우, 세포 또는 피부 침투성이 한층 증진된 구형 구조체 (일 예로, 리포좀)를 제조할 수 있다. 또한, 본 발명에서 제조된 구형 구조체 (일 예로, 리포좀)를 이용할 경우, 난용성 물질 (피부기능성 물질 또는 약리학적 효능 물질)을 구조체 내부에 탑재시켜 피부 또는 세포로 효율적으로 수송할 수 있다. |
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