CONDENSED BENZODIAZEPINE DERIVATIVES AND CONJUGATES MADE THEREFROM

A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates. L'invention concerne un composé cap...

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Hauptverfasser:	CHENG, Heng, MCDONALD, Ivar M, SIVAPRAKASAM, Prasanna, CHOWDARI, Naidu S, GANGWAR, Sanjeev, IWUAGWU, Christiana I, PEESE, Kevin M
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates. L'invention concerne un composé capable d'inhiber la prolifération cellulaire, ayant une structure selon la formule (I) dans laquelle les variables sont telles que définies dans la description. De tels composés sont utiles en tant qu'agents anticancéreux, en particulier dans des conjugués anticorps-médicament.