BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTATION METABOLISM OF S. CEREVISIAE

BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTATION METABOLISM OF S. CEREVISIAE

The present invention relates to a genetically modified yeast strain, and to a method for the bioproduction of acetaldehyde using this strain. More particularly, the invention relates to a strain of S. cerevisiae which expresses an exogenous NADH oxidase and in which the gene ΑDH1 is inactivated. Cu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GOGNIES, Sabine, GUICHEBARD, Pierre, BELARBI, Abdelkader
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to a genetically modified yeast strain, and to a method for the bioproduction of acetaldehyde using this strain. More particularly, the invention relates to a strain of S. cerevisiae which expresses an exogenous NADH oxidase and in which the gene ΑDH1 is inactivated. Cultured in a medium comprising approximately 5% sugars, in the presence of a bubbling process permitting continuous extraction of the acetaldehyde produced, said strain permits the ready production of acetaldehyde. La présente invention concerne une souche de levure génétiquement modifiée, ainsi qu'un procédé de bioproduction d'acétaldéhyde utilisant cette souche. Plus particulièrement, l'invention concerne une souche de S. cerevisiae exprimant une NADH oxydase exogène et dans laquelle le gène ΑDH1 est inactivé. Mise en culture dans un milieu comprenant environ 5% de sucres et en présence d'un bullage permettant l'extraction en continu de l'acétaldéhyde produit, cette souche permet une production aisée d'acétaldéhyde.